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desvenlafaxine will boost the amount or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) lower the CYP2D6 substrate dose by as much as 50%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive times right aw